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Severe bronchiolitis profiles and risk of recurrent wheeze by age 3 years

By |2018-12-13T14:36:20+00:00December 13th, 2018|

Background A better understanding of bronchiolitis heterogeneity might help clarify its relationship with the development of recurrent wheezing and asthma. Objectives We sought to identify severe bronchiolitis profiles using a clustering approach and to investigate for the first time their association with allergy/inflammatory biomarkers, nasopharyngeal microbiota, and development of recurrent wheezing by age 3 years. Methods [...]

Chronic obstructive pulmonary disease mortality, a competing risk analysis

By |2018-12-13T14:36:14+00:00December 13th, 2018|

Abstract Background Current risk factors for Chronic Obstructive Pulmonary Disease mortality focus only on overall and respiratory death. We investigated whether risk factors for each specific cause of mortality are different depending on the outcome under consideration. Methods This retrospective cohort study included patients with a clinical diagnosis of COPD, older than 40, greater than [...]

Breast cancer risk after childbirth may persist more than 20 years

By |2018-12-13T14:36:10+00:00December 13th, 2018|

The increased risk for breast cancer after giving birth can last for around 24 years, according to findings published in Annals of Internal Medicine. “Parity is widely recognized as protective for breast cancer, but breast cancer risk may be increased shortly after childbirth,” Hazel B. Nichols, PhD, assistant professor in the department of epidemiology at the University of North Carolina [...]

Life in Deep Earth Totals 15 to 23 Billion Tonnes of Carbon—Hundreds of Times More than Humans

By |2018-12-13T14:36:04+00:00December 13th, 2018|

Barely living “zombie” bacteria and other forms of life constitute an immense amount of carbon deep within Earth’s subsurface—245 to 385 times greater than the carbon mass of all humans on the surface, according to scientists nearing the end of a 10-year international collaboration to reveal Earth’s innermost secrets. 10 DECEMBER 2018 Contacts Terry Collins, [...]

What’s holding pharma back from the next antibiotic breakthrough?

By |2018-12-13T14:35:52+00:00December 13th, 2018|

By PETER BAK DECEMBER 10, 2018 In the five years since the alarm sounded about so-called superbugs, the world has continued to grapple with the staggering health and economic impacts of antibiotic resistance and mounting resistance to antibiotics of last resort. In the U.S. alone, antibiotic resistance adds $20 billion to $35 billion in direct health care costs each year, along with [...]

Binning microbial genomes using deep learning

By |2018-12-13T14:35:47+00:00December 13th, 2018|

Abstract Identification and reconstruction of microbial species from metagenomics wide genome sequencing data is an important and challenging task. Current existing approaches rely on gene or contig co-abundance information across multiple samples and k-mer composition information in the sequences. Here we use recent advances in deep learning to develop an algorithm that uses variational autoencoders [...]

Ebola count in DRC hits 500 in growing outbreak

By |2018-12-13T14:35:41+00:00December 13th, 2018|

The world’s second-largest Ebola outbreak hit another milestone today, as the Democratic Republic of the Congo (DRC) recorded 2 new cases, raising outbreak totals to 500, including 289 deaths. Of the four new deaths recorded today, two are community deaths in Beni and Mabalako, which took place outside a hospital or Ebola treatment center, raising [...]

McDonald’s sets timeline to cut antibiotics in beef supply

By |2018-12-13T14:35:35+00:00December 13th, 2018|

Editor’s note: This story was updated later on Dec 11 with comments from Paul Plummer, DVM. McDonald’s today announced a new policy to reduce the use of medically important antibiotics in its beef supply chain. The company says it will partner with supplying beef producers in the United States and nine other countries—Australia, Brazil, Canada, France, [...]

Klebsiella pneumoniae causing urinary tract infections in companion animals and humans: population structure, antimicrobial resistance and virulence genes

By |2018-12-13T14:35:29+00:00December 13th, 2018|

Abstract Objectives To characterize the population structure, antimicrobial resistance and virulence genes of Klebsiella spp. isolated from dogs, cats and humans with urinary tract infections (UTIs). Methods Klebsiella spp. from companion animals (n = 27) and humans (n = 77) with UTI were tested by the disc diffusion method against 29 antimicrobials. Resistant/intermediate isolates were tested by PCR for 16 resistance genes. [...]

UK children face winter health crisis due to pollution, say doctors

By |2018-12-12T14:38:07+00:00December 12th, 2018|

The Guardian has taken point in the UK reporting on the impacts of pollution on the health of the people of the UK.   Great read…   Thousands of children are facing hospital this winter as cold weather and the UK’s air pollution crisis combine to create potentially deadly conditions for young people, doctors have warned. [...]