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Why Knees Hurt

By |2018-10-21T05:51:19+00:00October 21st, 2018|

It’s Complicated Your knees have lots of moving parts, and you use them a lot, so lots of things can go wrong. Too much of one kind of motion, especially if you don’t work up to it, can lead to “overuse” injuries. Simple wear and tear is a problem, especially as you age. Accidents can [...]

Apples

By |2018-10-21T05:51:15+00:00October 21st, 2018|

Does eating an apple every day really keep the doctor away? Apples are certainly popular—ranking among the top three fruits produced around the world. They are easy to store and transport, and as a result, are typically available year-round in the U.S. In this piece we’ll explore how apples may benefit health and the best types for [...]

New Ibrunitib Combo a Powerful Combatant Against Relapsed/Refractory Multiple Myeloma

By |2018-10-21T05:44:45+00:00October 21st, 2018|

Encouraging results for an incurable bone cancer A multicenter phase 1 trial of ibrunitib, carfilzomib and dexamethasone for patients with relapsed or refractory multiple myeloma (RRMM) demonstrated a 67 percent overall response rate. Jason Valent, MD, associate staff in the Department of Hematology and Medical Oncology at Cleveland Clinic Cancer Center, is enthusiastic about the results of the study [...]

How to Calculate Mutation Rate for Evolutionary Biology

By |2018-10-21T05:44:10+00:00October 21st, 2018|

Four ways to study mutation rate, a crucial statistic in studies of evolution Mutation: it’s the raw material for evolution. That makes knowing the rate at which it occurs crucial to the study of evolutionary biology. Mutation rate figures into all kinds of calculations. For example, the “molecular clocks” that evolutionary biologists use to estimate [...]

Comparative Efficacy of Anti IL-4, IL-5 and IL-13 Drugs for Treatment of Eosinophilic Asthma: A Network Meta-analysis

By |2018-10-21T05:43:31+00:00October 21st, 2018|

Background Several new biologics have been studied in patients with eosinophilic asthma with varying degrees of response on clinical outcomes. No head-to-head trial has directly compared the efficacy of these drugs. Objective To synthesize data on the relative efficacy of benralizumab, dupilumab, lebrikizumab, mepolizumab, reslizumab, and tralokinumab using network meta-analysis. Data sources We searched PubMed [...]

Discovery of mcr-1-Mediated Colistin Resistance in a Highly Virulent Escherichia coli Lineage

By |2018-10-21T05:43:25+00:00October 21st, 2018|

ABSTRACT Resistance to last-line polymyxins mediated by the plasmid-borne mobile colistin resistance gene (mcr-1) represents a new threat to global human health. Here we present the complete genome sequence of an mcr-1-positive multidrug-resistant Escherichia coli strain (MS8345). We show that MS8345 belongs to serotype O2:K1:H4, has a large 241,164-bp IncHI2 plasmid that carries 15 other antibiotic resistance genes [...]

C.difficile Survives commercial laundering of bed hospital sheets

By |2018-10-21T05:43:19+00:00October 21st, 2018|

Commercial washing and drying under United Kingdom health care laundry policy failed to remove all Clostridium difficile, also known as Clostridioides difficile, spores on hospital bedsheets, according to study results published in Infection Control & Hospital Epidemiology. “Our research found that standard laundering methods in U.K. hospitals failed to remove all traces of … C. difficile, suggesting that linens [...]

The burden of congenital Chagas disease and implementation of molecular diagnostic tools in Latin America

By |2018-10-21T05:43:01+00:00October 21st, 2018|

Abstract It is estimated that between 8000 and 15 000 Trypanosoma cruzi infected babies are born every year to infected mothers in Chagas disease endemic countries. Currently, poor access to and performance of the current diagnostic algorithm, based on microscopy at birth and serology at 8–12 months after delivery, is one of the barriers to congenital Chagas disease [...]

Measles outbreak raging in Europe could be brought to U.S., doctors warn

By |2018-10-21T05:42:55+00:00October 21st, 2018|

A raging measles outbreak in Europe may be a warning sign of what could occur in the U.S. if something doesn’t change soon, experts say. So far this year, there have been 41,000 cases in Europe and 40 deaths, according to the World Health Organization. The European experience may offer a window on how quickly things can [...]