Comparative Efficacy of Anti IL-4, IL-5 and IL-13 Drugs for Treatment of Eosinophilic Asthma: A Network Meta-analysis

By |2018-10-21T05:43:31+00:00October 21st, 2018|

Background Several new biologics have been studied in patients with eosinophilic asthma with varying degrees of response on clinical outcomes. No head-to-head trial has directly compared the efficacy of these drugs. Objective To synthesize data on the relative efficacy of benralizumab, dupilumab, lebrikizumab, mepolizumab, reslizumab, and tralokinumab using network meta-analysis. Data sources We searched PubMed [...]

Discovery of mcr-1-Mediated Colistin Resistance in a Highly Virulent Escherichia coli Lineage

By |2018-10-21T05:43:25+00:00October 21st, 2018|

ABSTRACT Resistance to last-line polymyxins mediated by the plasmid-borne mobile colistin resistance gene (mcr-1) represents a new threat to global human health. Here we present the complete genome sequence of an mcr-1-positive multidrug-resistant Escherichia coli strain (MS8345). We show that MS8345 belongs to serotype O2:K1:H4, has a large 241,164-bp IncHI2 plasmid that carries 15 other antibiotic resistance genes [...]

C.difficile Survives commercial laundering of bed hospital sheets

By |2018-10-21T05:43:19+00:00October 21st, 2018|

Commercial washing and drying under United Kingdom health care laundry policy failed to remove all Clostridium difficile, also known as Clostridioides difficile, spores on hospital bedsheets, according to study results published in Infection Control & Hospital Epidemiology. “Our research found that standard laundering methods in U.K. hospitals failed to remove all traces of … C. difficile, suggesting that linens [...]

The burden of congenital Chagas disease and implementation of molecular diagnostic tools in Latin America

By |2018-10-21T05:43:01+00:00October 21st, 2018|

Abstract It is estimated that between 8000 and 15 000 Trypanosoma cruzi infected babies are born every year to infected mothers in Chagas disease endemic countries. Currently, poor access to and performance of the current diagnostic algorithm, based on microscopy at birth and serology at 8–12 months after delivery, is one of the barriers to congenital Chagas disease [...]

Measles outbreak raging in Europe could be brought to U.S., doctors warn

By |2018-10-21T05:42:55+00:00October 21st, 2018|

A raging measles outbreak in Europe may be a warning sign of what could occur in the U.S. if something doesn’t change soon, experts say. So far this year, there have been 41,000 cases in Europe and 40 deaths, according to the World Health Organization. The European experience may offer a window on how quickly things can [...]

How parked cars affect pollutant dispersion at street level in an urban street canyon? A CFD modelling exercise assessing geometrical detailing and pollutant decay rates

By |2018-10-19T05:24:23+00:00October 19th, 2018|

Highlights •    Parked cars can act as a passive barrier to improve air quality on footpaths. •    A mesh discretization assessment is key prior to a street canyon modelling study. •    Geometrical detailing of passive barriers impact results from air quality models. •    Coarse car geometry can overestimate personal exposure on [...]

Report highlights declining sales of vet antibiotics in Europe

By |2018-10-19T05:24:13+00:00October 19th, 2018|

A report yesterday from the European Medicines Agency (EMA) shows a significant drop in overall sales of veterinary antibiotics across Europe. The data from the EMA’s eighth European Surveillance of Veterinary Antimicrobial Consumption (ESVAC) report show a 20.1% decline in sales of antibiotics for food-producing animals in 25 European Union (EU) countries from 2011 through [...]

From ward to washer: The survival of Clostridium difficile spores on hospital bed sheets through a commercial UK NHS healthcare laundry process

By |2018-10-19T05:24:08+00:00October 19th, 2018|

Abstract ObjectiveTo quantify the survival of Clostridium difficile spores on hospital bed sheets through the United Kingdom National Health System (UK NHS) healthcare laundry process (Health Technical Memorandum (HTM) 01-04) in vitro and on bed sheets from patients with C. difficile through the commercial laundry. MethodsClostridium difficile spores were inoculated onto cotton sheets and laundered through a simulated washer extractor [...]

Comparison of the Superpolymyxin™ and CHROMID® Colistin R screening media for the detection of colistin-resistant Enterobacteriaceae from spiked rectal swabs

By |2018-10-19T05:24:00+00:00October 19th, 2018|

ABSTRACT The dissemination of carbapenemase-producing Enterobacteriaceae (CPE), has led to the increased use of colistin, which resulted in the emergence of colistin-resistant Enterobacteriaceae worldwide. One of the most threatening scenarios is the dissemination of colistin-resistance in CPE, particularly the plasmid-encoded resistance MCR. Thus, it becomes now mandatory to possess reliable media to screen for colistin-resistant Gram-negative isolates, especially Enterobacteriaceae. In [...]

A New Piece of the Alzheimer’s Puzzle

By |2018-10-19T05:23:54+00:00October 19th, 2018|

For the past few decades, researchers have been busy uncovering genetic variants associated with an increased risk of Alzheimer’s disease (AD) [1]. But there’s still a lot to learn about the many biological mechanisms that underlie this devastating neurological condition that affects as many as 5 million Americans [2]. As an example, an NIH-funded research [...]